ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate
• CAS No.: 96734-82-6
• Molecular Formula: C₁₆H₁₅F₃N₂O₃
• Molecular Weight: 340.302

Synonyms:ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate

Chemical Property of ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate

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Technology Process of ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate

There total 4 articles about ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

acetylacetone (123-54-6,81235-32-7) + ethyl chloro[(3-trifluoromethylphenyl)hydrazono]acetate → ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate (96734-82-6)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 22h;

DOI:10.1134/S1070428008090182

Reference yield: 70.0%

chloro{[3-(trifluoromethyl)phenyl]hydrazono}-acetic acid, ethyl ester (35229-84-6) + acetylacetone (123-54-6,81235-32-7) → ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate (96734-82-6)

Guidance literature:

With sodium ethanolate; In diethyl ether; ethanol; for 15h; Ambient temperature;

Reference yield: 62.0%

diazoacetic acid ethyl ester (623-73-4) + 3-(trifluoromethyl)benzenediazonium tetrafluoroborate (454-87-5) + acetylacetone (123-54-6,81235-32-7) → ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate (96734-82-6)

Guidance literature:

With cobalt phosphate; In acetonitrile; at 25 ℃; for 12h;

DOI:10.1021/acs.orglett.8b00750

upstream raw materials:

chloro{[3-(trifluoromethyl)phenyl]hydrazono}-acetic acid, ethyl ester

acetylacetone

3-trifluoromethylaniline

diazoacetic acid ethyl ester

Downstream raw materials:

3,4-dimethyl-2-(3-trifluoromethylphenyl)-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one

1-(3-trifluoromethylphenyl)-3-carboxy-4-acetyl-5-methylpyrazole

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