3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide

Base Information

Chemical Name:3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide
CAS No.:1268252-80-7
Molecular Formula:C₂₁H₂₀ClF₂N₃O₃
Molecular Weight:435.858
Hs Code.:

Synonyms:3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide

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Chemical Property of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide

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Technology Process of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide

There total 3 articles about 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1268252-73-8
3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [1-(4-iodo-phenyl)-ethyl]-methoxy-amide

: 106-48-9,82344-39-6
4-chloro-phenol

: 1268252-80-7
3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide

Guidance literature:: With dimethylaminoacetic acid; caesium carbonate; copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 0.833333h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 896718-37-9
1-(4-iodophenyl)ethan-1-one O-methyl oxime

: 1268252-80-7
3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / 15 - 20 °C

2: triethylamine / dichloromethane / 20 °C / Cooling with ice bath

3: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / N,N-dimethyl-formamide / 0.83 h / 100 °C / Microwave irradiation; Inert atmosphere

With dimethylaminoacetic acid; sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 13329-40-3
4-Iodoacetophenone

: 1268252-80-7
3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol / 4 h / 20 °C

2: sodium cyanoborohydride; acetic acid / 15 - 20 °C

3: triethylamine / dichloromethane / 20 °C / Cooling with ice bath

4: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / N,N-dimethyl-formamide / 0.83 h / 100 °C / Microwave irradiation; Inert atmosphere

With dimethylaminoacetic acid; sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; copper(l) iodide; In methanol; dichloromethane; N,N-dimethyl-formamide;