1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine

Base Information

Chemical Name:1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine
CAS No.:179557-58-5
Molecular Formula:C₂₂H₂₈FN₅
Molecular Weight:381.496
Hs Code.:

Synonyms:1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine

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Technology Process of 1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine

There total 5 articles about 1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 7677-24-9
trimethylsilyl cyanide

: 67-64-1
acetone

: 1027670-93-4
1-benzyl-4-[N-methyl-N-(3-amino-6-fluoro-2-pyridinyl)amino]piperidine

: 179557-58-5
1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine

Guidance literature:: With zinc(II) chloride;
DOI:10.1021/jm960158n

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 179557-58-5
1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / sodium cyanoborohydride, 4 Angstroem molecular sieves / methanol / 24 h / Ambient temperature

2: 55 percent / K₂CO₃ / acetonitrile / 120 h / Ambient temperature

3: H₂ / 10percent Pd/C / methanol / 2 h

4: 43 percent / ZnCl₂

With 4 A molecular sieve; hydrogen; sodium cyanoborohydride; potassium carbonate; zinc(II) chloride; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm960158n

Reference yield:

: 7006-50-0
1-benzyl-N-methylpiperidin-4-amine

: 179557-58-5
1-Benzyl-4-[N-methyl-N-(3-(1-methyl-1-cyanoethyl)amino-6-fluoro-2-pyridinyl)amino]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / K₂CO₃ / acetonitrile / 120 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 2 h

3: 43 percent / ZnCl₂

With hydrogen; potassium carbonate; zinc(II) chloride; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm960158n