5-chloro-N-(4-fluorophenyl)-2-hydroxy-3-[(E)-2-nitroethenyl]benzamide

Base Information

Chemical Name:5-chloro-N-(4-fluorophenyl)-2-hydroxy-3-[(E)-2-nitroethenyl]benzamide
CAS No.:111870-32-7
Molecular Formula:C₁₅H₁₀ClFN₂O₄
Molecular Weight:336.707
Hs Code.:

Synonyms:111870-32-7;5-Chloro-N-(4-fluorophenyl)-2-hydroxy-3-((E)-2-nitroethenyl)benzamide

Suppliers and Price of 5-chloro-N-(4-fluorophenyl)-2-hydroxy-3-[(E)-2-nitroethenyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-chloro-N-(4-fluorophenyl)-2-hydroxy-3-[(E)-2-nitroethenyl]benzamide

Chemical Property:

Vapor Pressure:3.9E-09mmHg at 25°C
Boiling Point:461.4°C at 760 mmHg
Flash Point:232.9°C
Density:1.529g/cm³
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:336.0313127
Heavy Atom Count:23
Complexity:463

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1NC(=O)C2=CC(=CC(=C2O)C=C[N+](=O)[O-])Cl)F
Isomeric SMILES:C1=CC(=CC=C1NC(=O)C2=CC(=CC(=C2O)/C=C/[N+](=O)[O-])Cl)F

Technology Process of 5-chloro-N-(4-fluorophenyl)-2-hydroxy-3-[(E)-2-nitroethenyl]benzamide

There total 4 articles about 5-chloro-N-(4-fluorophenyl)-2-hydroxy-3-[(E)-2-nitroethenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 111870-29-2
5-chloro-3-(2-nitroethenyl)salicyloyl chloride

: 371-40-4
4-fluoroaniline

: 111870-32-7
5-Chloro-N-(4-fluoro-phenyl)-2-hydroxy-3-((Z)-2-nitro-vinyl)-benzamide

Guidance literature:: With triethylamine; In benzene; 1 h, 5 deg C; 1 h, room temperature;

Reference yield:

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 111870-32-7
5-Chloro-N-(4-fluoro-phenyl)-2-hydroxy-3-((Z)-2-nitro-vinyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 42 percent / NaOH / H₂O / 30 h / Heating

2: 30 percent / n-butylamine / acetic acid / 4 h / Heating

3: SOCl₂ / 0.33 h / Heating

4: 65 percent / triethylamine / benzene / 1 h, 5 deg C; 1 h, room temperature

With sodium hydroxide; thionyl chloride; N-butylamine; triethylamine; In water; acetic acid; benzene;

Reference yield:

: 111870-27-0
5-chloro-3-formyl-2-hydroxybenzoic acid

: 111870-32-7
5-Chloro-N-(4-fluoro-phenyl)-2-hydroxy-3-((Z)-2-nitro-vinyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / n-butylamine / acetic acid / 4 h / Heating

2: SOCl₂ / 0.33 h / Heating

3: 65 percent / triethylamine / benzene / 1 h, 5 deg C; 1 h, room temperature

With thionyl chloride; N-butylamine; triethylamine; In acetic acid; benzene;