1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone

Base Information

• Chemical Name: 1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone
• CAS No.: 62019-04-9
• Molecular Formula: C₁₄H₁₄N₆O₆
• Molecular Weight: 362.302

Synonyms:1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone

Chemical Property of 1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone

Chemical Property:

Purity/Quality:

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Technology Process of 1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone

There total 4 articles about 1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-2,2-dimethoxy-3-<(p-carboxyphenyl)amino>propane (77773-80-9) → 1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone (62019-04-9)

Guidance literature:

With hydrogenchloride; In trifluoroacetic acid; at 55 ℃; for 0.5h;

DOI:10.1021/jo00328a042

Reference yield:

N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid (77773-78-5) → 1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone (62019-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 5percent palladium on carbon / methanol / 18 h / 1292.9 Torr

2: 80 percent / methanol / 3 h / Heating

3: 86 percent / 0.1 N HCl / trifluoroacetic acid / 0.5 h / 55 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; trifluoroacetic acid;

DOI:10.1021/jo00328a042

Reference yield:

4-[(3-Azido-2,2-dimethoxy-propyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid ethyl ester (77773-77-4) → 1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-3-<(p-carboxyphenyl)amino>-2-propanone (62019-04-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / 1 N NaOH / tetrahydrofuran / 18 h

2: H₂ / 5percent palladium on carbon / methanol / 18 h / 1292.9 Torr

3: 80 percent / methanol / 3 h / Heating

4: 86 percent / 0.1 N HCl / trifluoroacetic acid / 0.5 h / 55 °C

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; trifluoroacetic acid;

DOI:10.1021/jo00328a042

upstream raw materials:

1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-2,2-dimethoxy-3-<(p-carboxyphenyl)amino>propane

N-(1-Amino-2,2-dimethoxypropyl)-p-aminobenzoic acid

N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid

4-[(3-Azido-2,2-dimethoxy-propyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid ethyl ester

Downstream raw materials:

Pteroic acid

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