(S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid

Base Information

Chemical Name:(S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid
CAS No.:1131870-29-5
Molecular Formula:C₂₇H₄₀N₄O₆
Molecular Weight:516.638
Hs Code.:

Synonyms:(S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid

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Chemical Property of (S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid

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Technology Process of (S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid

There total 1 articles about (S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1131870-27-3
(S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid methyl ester

: 1131870-29-5
(S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid

Guidance literature:: (S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid methyl ester; With methanol; lithium hydroxide; water; at 0 ℃; for 5h;

With water; citric acid; pH=4 - 5;

Reference yield:

: 123-75-1
pyrrolidine

: 1131870-29-5
(S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid

: 1131870-77-3
[(S)-1-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}-benzyl)-2-oxo-2-pyrrolidin-1-ylethyl]carbamic acid tert-butyl ester

Guidance literature:: (S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃; for 0.166667h;

pyrrolidine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 504-78-9
1,3-thiazolidine

: 1131870-29-5
(S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid

: 1131870-32-0
[(S)-1-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}-benzyl)-2-oxo-2-thiazolidin-3-ylethyl]carbamic acid tert-butyl ester

Guidance literature:: (S)-2-tert-butoxycarbonylamino-3-(4-{3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}phenyl)propionic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

1,3-thiazolidine; In tetrahydrofuran; at 20 ℃; for 16h;