tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate
CAS No.:1610460-60-0
Molecular Formula:C₂₁H₂₉NO₆S
Molecular Weight:423.53
Hs Code.:

Synonyms:tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate

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Chemical Property of tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate

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Technology Process of tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate

There total 9 articles about tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: tert-butyl 3-hydroxy-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]piperidine-1-carboxylate

: 1610460-60-0
tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate

Guidance literature:: tert-butyl 3-hydroxy-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]piperidine-1-carboxylate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 - -65 ℃; for 0.75h; Inert atmosphere;

With triethylamine; In dichloromethane; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2014.04.037

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 1610460-60-0
tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

2.1: sodium hydroxide / water; acetonitrile / 24 h / 95 °C

3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 - -65 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

With oxalyl dichloride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In dichloromethane; water; acetonitrile; 3.1: |Swern Oxidation;
DOI:10.1016/j.tet.2014.04.037

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1610460-60-0
tert-butyl-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]-3-oxopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 16 h / 0 - 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

3.1: sodium hydroxide / water; acetonitrile / 24 h / 95 °C

4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 - -65 °C / Inert atmosphere

4.2: 1 h / Inert atmosphere

With oxalyl dichloride; sodium hydrogencarbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; acetonitrile; 4.1: |Swern Oxidation;
DOI:10.1016/j.tet.2014.04.037