N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

Base Information

Chemical Name:N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine
CAS No.:1160714-65-7
Molecular Formula:C₂₂H₄₀INO₄Si₂
Molecular Weight:565.639
Hs Code.:

Synonyms:N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

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Chemical Property of N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

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Technology Process of N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

There total 6 articles about N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 916977-11-2
1-iodo-2-iodomethyl-4,5-dimethoxybenzene

: 1160714-58-8
2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

: 1160714-65-7
N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; Reflux;
DOI:10.1021/ol900806m

Reference yield:

: 1160714-63-5
tert-butyl 2,6-dimethyl-4-(trimethylsilyl)-1,3-oxazinane-3-carboxylate

: 1160714-65-7
N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1: water; toluene-4-sulfonic acid / methanol

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate

3: toluene-4-sulfonic acid / benzene

4: trifluoroacetic acid / dichloromethane

5: potassium carbonate / acetonitrile

6: potassium carbonate / acetonitrile / 8 h / Reflux

With water; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; dichloromethane; ethyl acetate; acetonitrile; benzene;
DOI:10.1002/ejoc.201001263

Reference yield:

: 1160714-59-9
tert-butyl 3-hydroxy-1-(trimethylsilyl)butylcarbamate

: 1160714-65-7
N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate

2: toluene-4-sulfonic acid / benzene

3: trifluoroacetic acid / dichloromethane

4: potassium carbonate / acetonitrile

5: potassium carbonate / acetonitrile / 8 h / Reflux

With potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; ethyl acetate; acetonitrile; benzene;
DOI:10.1002/ejoc.201001263