methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate

Base Information

Chemical Name:methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate
CAS No.:1160714-57-7
Molecular Formula:C₂₆H₄₅NO₆Si₂
Molecular Weight:523.817
Hs Code.:

Synonyms:methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate

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Chemical Property of methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate

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Technology Process of methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate

There total 7 articles about methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1160714-65-7
N-(2-iodo-4,5-dimethoxybenzyl)-2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)ethanamine

: 124582-37-2
methyl 2-(tributylstannanyl)-2-propenoate

: 1160714-57-7
methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; lithium chloride; In dimethyl sulfoxide; at -78 - 60 ℃; Inert atmosphere;
DOI:10.1021/ol900806m

Reference yield:

: 1160714-63-5
tert-butyl 2,6-dimethyl-4-(trimethylsilyl)-1,3-oxazinane-3-carboxylate

: 1160714-57-7
methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 7 steps

1: water; toluene-4-sulfonic acid / methanol

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate

3: toluene-4-sulfonic acid / benzene

4: trifluoroacetic acid / dichloromethane

5: potassium carbonate / acetonitrile

6: potassium carbonate / acetonitrile / 8 h / Reflux

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; lithium chloride / dimethyl sulfoxide / 3 h / 20 - 60 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; copper(l) chloride; lithium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile; benzene; 7: Stille coupling;
DOI:10.1002/ejoc.201001263

Reference yield:

: 1160714-64-6
tert-butyl 3-oxo-1-(trimethylsilyl)butylcarbamate

: 1160714-57-7
methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / benzene

2: trifluoroacetic acid / dichloromethane

3: potassium carbonate / acetonitrile

4: potassium carbonate / acetonitrile / 8 h / Reflux

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; lithium chloride / dimethyl sulfoxide / 3 h / 20 - 60 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; copper(l) chloride; lithium chloride; In dichloromethane; dimethyl sulfoxide; acetonitrile; benzene; 5: Stille coupling;
DOI:10.1002/ejoc.201001263