tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Base Information

Chemical Name:tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate
CAS No.:1268383-17-0
Molecular Formula:C₃₄H₅₀N₆O₈Si
Molecular Weight:698.892
Hs Code.:

tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Synonyms:tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

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Chemical Property of tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

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Technology Process of tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

There total 11 articles about tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1268383-16-9
tert-butyl N-[4-amino-5-(benzyloxy)-1,2-dihydro-1-(2-(trimethylsilyl)ethyl)-2-oxopyrimido[4,5-d]pyrimidin-7-yl]-N-methylcarbamate

: 1268383-17-0
tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; for 12h; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: C₂₃H₃₅N₅O₄Si

: 1268383-17-0
tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 - 80 °C / Inert atmosphere

2: dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3: ammonia / methanol / 3 h / 20 °C / Inert atmosphere

4: dmap; triethylamine / tetrahydrofuran / 12 h / Inert atmosphere

With dmap; ammonia; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: 1268383-14-7
tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

: 1268383-17-0
tert-butyl N-[4-(benzyloxy)-5-(di-tert-butylaminodicarbonate)-7-oxo-8-(2-(trimethylsilyl)ethyl)-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: ammonia / methanol / 3 h / 20 °C / Inert atmosphere

3: dmap; triethylamine / tetrahydrofuran / 12 h / Inert atmosphere

With dmap; ammonia; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetlet.2010.11.122