tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

Base Information

Chemical Name:tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate
CAS No.:1268383-14-7
Molecular Formula:C₂₃H₃₃N₅O₃Si
Molecular Weight:455.632
Hs Code.:

Synonyms:tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

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Chemical Property of tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

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Technology Process of tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

There total 8 articles about tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₅N₅O₄Si

: 1268383-14-7
tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

Guidance literature:: With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 - 80 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: tert-butyl 4-(benzyloxy)-5-formyl-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl)carbamate

: 1268383-14-7
tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 3 h / 20 °C / Inert atmosphere

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 - 80 °C / Inert atmosphere

With pyridine; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: 1268383-12-5
4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

: 1268383-14-7
tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2: pyridine / 3 h / 20 °C / Inert atmosphere

3: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 - 80 °C / Inert atmosphere

With pyridine; dmap; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2010.11.122