tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate

Base Information

Chemical Name:tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate
CAS No.:1268383-15-8
Molecular Formula:C₂₄H₃₄N₆O₄Si
Molecular Weight:498.657
Hs Code.:

Synonyms:tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate

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Chemical Property of tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate

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Technology Process of tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate

There total 9 articles about tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1268383-14-7
tert-Butyl 4-(benzyloxy)-5-cyano-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl) carbamate

: 27738-96-1
chlorocarbonyl isocyanate

: 1268383-15-8
tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: tert-butyl 4-(benzyloxy)-5-formyl-6-(2-(trimethylsilyl)ethylamino)pyrimidin-2-yl(methyl)carbamate

: 1268383-15-8
tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 3 h / 20 °C / Inert atmosphere

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 - 80 °C / Inert atmosphere

3: dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With pyridine; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: 1268383-10-3
2,4-dichloro-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

: 1268383-15-8
tert-butyl 4-(benzyloxy)-5-cyano-6-(1-(2-(trimethylsilyl)ethyl)ureido)pyrimidin-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere; Reflux

3.1: dmap; triethylamine / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

4.1: pyridine / 3 h / 20 °C / Inert atmosphere

5.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 - 80 °C / Inert atmosphere

6.1: dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; sodium hydride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2010.11.122