4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate

Base Information

Chemical Name:4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate
CAS No.:139766-12-4
Molecular Formula:C₃₇H₄₄O₇SSi
Molecular Weight:660.904
Hs Code.:

Synonyms:4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate

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Chemical Property of 4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate

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Technology Process of 4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate

There total 8 articles about 4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 98-88-4
benzoyl chloride

: 139766-01-1
1-(tert-butyldimethylsilyloxy)-1-phenyl-3-(phenylsulfonyl)propane

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 139766-12-4
4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate

Guidance literature:: 1-(tert-butyldimethylsilyloxy)-1-phenyl-3-(phenylsulfonyl)propane; 2,4-Dimethoxybenzaldehyde; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

benzoyl chloride; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;
DOI:10.1016/S0040-4020(99)00832-7

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 139766-12-4
4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; DMPU / tetrahydrofuran; hexane / 0.25 h / 25 °C

1.2: 96 percent / triethylamine / tetrahydrofuran / 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 80 percent / n-BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane; 1.1: Addition / 1.2: Substitution / 2.1: Substitution / 2.2: Esterification;
DOI:10.1016/S0040-4020(99)00832-7

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 139766-12-4
4-(tert-butyldimethylsilyloxy)-1-(2,4-dimethoxyphenyl)-4-phenyl-2-(phenylsulfonyl)butanol benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; DMPU / tetrahydrofuran; hexane / 0.25 h / 25 °C

1.2: 96 percent / triethylamine / tetrahydrofuran / 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 80 percent / n-BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane; 1.1: Addition / 1.2: Substitution / 2.1: Substitution / 2.2: Esterification;
DOI:10.1016/S0040-4020(99)00832-7