2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester

Base Information

• Chemical Name: 2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester
• CAS No.: 146444-96-4
• Molecular Formula: C₁₁H₁₂FIO₄
• Molecular Weight: 354.117
• Mol file: 146444-96-4.mol

Synonyms:2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester

Chemical Property of 2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester

There total 2 articles about 2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-fluoroethyl bromide (762-49-2) + methyl 5-iodo-3-methoxysalicylate (134419-44-6) → 2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester (146444-96-4)

Guidance literature:

With potassium carbonate; In acetone; for 48h; Heating;

DOI:10.1021/jm00054a005

Reference yield:

3-methoxymethylsalicylate (6342-70-7) → 2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester (146444-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / NaI, NaOH, aq. 5percent NaClO / methanol / 1 h / 0 - 3 °C

2: 86 percent / K₂CO₃ / acetone / 48 h / Heating

With sodium hydroxide; sodium hypochlorite; potassium carbonate; sodium iodide; In methanol; acetone;

DOI:10.1021/jm00054a005

Reference yield: 79.0%

2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoic acid methyl ester (146444-96-4) → 2-(2-fluoroethoxy)-5-iodo-3-methoxybenzoic acid (146444-97-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00054a005

upstream raw materials:

2-fluoroethyl bromide

methyl 5-iodo-3-methoxysalicylate

3-methoxymethylsalicylate

Downstream raw materials:

2-(2-fluoroethoxy)-5-iodo-3-methoxybenzoic acid

2-(2-Fluoro-ethoxy)-5-iodo-3-methoxy-benzoyl chloride