2-methyl-5-(4-nitrophenyl)-2H-tetrazole

Base Information

• Chemical Name: 2-methyl-5-(4-nitrophenyl)-2H-tetrazole
• CAS No.: 43131-48-2
• Molecular Formula: C8H7 N5 O2
• Molecular Weight: 205.176
• Mol file: 43131-48-2.mol

Synonyms:2-Methyl-5-(4-nitrophenyl)-2H-tetrazole;2-Methyl-5-(p-nitrophenyl)tetrazole; NSC 282053

Chemical Property of 2-methyl-5-(4-nitrophenyl)-2H-tetrazole

Chemical Property:

• Vapor Pressure: 6.22E-07mmHg at 25°C
• Boiling Point: 410°Cat760mmHg
• Flash Point: 201.8°C
• Density: 1.53g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-5-(4-nitrophenyl)-2H-tetrazole

There total 10 articles about 2-methyl-5-(4-nitrophenyl)-2H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-(4-nitrophenyl)-1H-1,2,3,4-tetrazole (16687-60-8) + carbonic acid dimethyl ester (616-38-6) → 4,1,20.2-methyl-5-(4-nitrophenyl)-2H-tetrazole (43131-48-2)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 130 ℃; for 20h; Green chemistry;

DOI:10.1002/jhet.2179

Reference yield: 80.0%

5-(4-nitrophenyl)-2H-tetrazole (16687-60-8) + methyl iodide (74-88-4) → 4,1,20.2-methyl-5-(4-nitrophenyl)-2H-tetrazole (43131-48-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

DOI:10.1016/j.ejmech.2019.04.042

Reference yield: 73.0%

tert.-butylhydroperoxide (75-91-2) + 5-(4-nitrophenyl)-2H-tetrazole (16687-60-8) → 4,1,20.2-methyl-5-(4-nitrophenyl)-2H-tetrazole (43131-48-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In water; acetonitrile; at 100 ℃; for 8h; Time; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.9b02875

upstream raw materials:

5-(4-nitrophenyl)-1H-1,2,3,4-tetrazole

dimethyl sulfate

methyl iodide

5-(4-nitrophenyl)-2H-tetrazole

Downstream raw materials:

4-(2-methyl-2H-tetrazol-5-yl)aniline

C₉H₁₀N₅O₂⁽¹⁺⁾*CH₃O₄S^(1-)

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