<3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester

Base Information

Chemical Name:<3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester
CAS No.:151331-96-3
Molecular Formula:C₁₉H₂₅ClN₅O₄P
Molecular Weight:453.865
Hs Code.:

Synonyms:<3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester

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Chemical Property of <3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester

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Technology Process of <3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester

There total 5 articles about <3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.4%

: 10310-21-1
2-Amino-6-chloropurin

: 151331-91-8
2-<3-(diethylphosphono)propoxy>benzyl bromide

: 151331-96-3
<3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 4h; Ambient temperature;
DOI:10.1021/jm00076a004

Reference yield:

: 151331-90-7
2-<3-(diethylphosphono)propoxy>benzyl alcohol

: 151331-96-3
<3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: PBr₃, NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

2: 52.4 percent / K₂CO₃ / dimethylformamide / 4 h / Ambient temperature

With phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00076a004

Reference yield:

: 1186-10-3
diethyl 3-(bromopropyl)phosphonic acid

: 151331-96-3
<3-<2-<(2-amino-1,6-dihydro-6-chloro-9H-purin-9-yl)methyl>phenoxy>-propyl>phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / K₂CO₃ / dimethylformamide / 7 h / 84 °C

2: PBr₃, NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

3: 52.4 percent / K₂CO₃ / dimethylformamide / 4 h / Ambient temperature

With phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00076a004