N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide

Base Information

Chemical Name:N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide
CAS No.:1378938-73-8
Molecular Formula:C₁₆H₁₄N₄O₃S
Molecular Weight:342.378
Hs Code.:

Synonyms:N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide

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Technology Process of N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide

There total 5 articles about N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1310739-63-9
N-methyl-4-(4-thioureidophenoxy)picolinamide

: 105-39-5
chloroacetic acid ethyl ester

: 1378938-73-8
N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide

Guidance literature:: With sodium acetate; In ethanol; at 60 ℃; for 6h;
DOI:10.1002/ardp.201100064

Reference yield:

: 53750-66-6
4-chloro-pyridine-2-carbonyl chloride

: 1378938-73-8
N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; methanol / 2 h / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 6 h / 80 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dichloromethane / 0.33 h / 0 °C

3.2: 5 h / 20 °C

4.1: ammonium hydroxide / 1,4-dioxane / 1 h / 0 °C

5.1: sodium acetate / ethanol / 6 h / 60 °C

With ammonium hydroxide; potassium tert-butylate; sodium acetate; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.201100064

Reference yield:

: 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

: 1378938-73-8
N-methyl-4-(4-(4-oxo-4,5-dihydro-1,3-thiazol-2-ylideneamino)phenoxy)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane / 0.33 h / 0 °C

1.2: 5 h / 20 °C

2.1: ammonium hydroxide / 1,4-dioxane / 1 h / 0 °C

3.1: sodium acetate / ethanol / 6 h / 60 °C

With ammonium hydroxide; sodium acetate; sodium hydrogencarbonate; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1002/ardp.201100064