(R)-methyl 2-cyano-2-(4-trifluoromethylphenyl)-2-trimethylsiloxyacetate

Base Information

Chemical Name:(R)-methyl 2-cyano-2-(4-trifluoromethylphenyl)-2-trimethylsiloxyacetate
CAS No.:1224978-73-7
Molecular Formula:C₁₄H₁₆F₃NO₃Si
Molecular Weight:331.367
Hs Code.:

Synonyms:(R)-methyl 2-cyano-2-(4-trifluoromethylphenyl)-2-trimethylsiloxyacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 2-cyano-2-(4-trifluoromethylphenyl)-2-trimethylsiloxyacetate

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Technology Process of (R)-methyl 2-cyano-2-(4-trifluoromethylphenyl)-2-trimethylsiloxyacetate

There total 1 articles about (R)-methyl 2-cyano-2-(4-trifluoromethylphenyl)-2-trimethylsiloxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 7677-24-9
trimethylsilyl cyanide

: 132115-87-8
(4-trifluoromethyl-phenyl)carbonyl-acetic acid methyl ester

: 1224978-73-7
(R)-methyl 2-cyano-2-(4-trifluoromethylphenyl)-2-trimethylsiloxyacetate

Guidance literature:: (4-trifluoromethyl-phenyl)carbonyl-acetic acid methyl ester; With [Ru{(S)-phgly}2{(S)-binap}]; lithium phenolate; In tetrahydrofuran; tert-butyl methyl ether; for 0.5h; Inert atmosphere;

trimethylsilyl cyanide; at -60 ℃; for 18h; optical yield given as %ee; Inert atmosphere;
DOI:10.1002/ejoc.200901501