N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine
CAS No.:222835-55-4
Molecular Formula:C₄₀H₃₆ClIN₂O₅
Molecular Weight:787.094
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

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Chemical Property of N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

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Technology Process of N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

There total 8 articles about N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 286374-28-5
(6-amino-4-benzyloxy-1-iodo-naphthalen-2-yl)-(3-chloro-allyl)-carbamic acid tert-butyl ester

: 222835-55-4
N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

Guidance literature:: With dmap; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/S0968-0896(00)00088-2

Reference yield:

: 222535-06-0
4-benzyloxy-6-nitro-2-naphthalenecarboxylic acid

: 222835-55-4
N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; diphenyl phosphoryl azide / 24 h / Molecular sieve; Reflux

2: sulfuric acid; 2-iodocyclopentane-1,3-dione / tetrahydrofuran; methanol

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrazine hydrate; iron(III) chloride / tetrahydrofuran; methanol

5: dmap / tetrahydrofuran

With 2-iodocyclopentane-1,3-dione; dmap; iron(III) chloride; sulfuric acid; diphenyl phosphoryl azide; sodium hydride; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 222535-07-1
N-(tert-butyloxycarbonyl)-4-benzyloxy-6-nitro-2-naphthylamine

: 222835-55-4
N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; 2-iodocyclopentane-1,3-dione / tetrahydrofuran; methanol

2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrazine hydrate; iron(III) chloride / tetrahydrofuran; methanol

4: dmap / tetrahydrofuran

With 2-iodocyclopentane-1,3-dione; dmap; iron(III) chloride; sulfuric acid; sodium hydride; hydrazine hydrate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;