1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

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Chemical Name:1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol
CAS No.:1361223-36-0
Molecular Formula:C₂₃H₃₀F₃N₃O₄S₂
Molecular Weight:533.636
Hs Code.:

Synonyms:1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

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Chemical Property of 1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

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Technology Process of 1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

There total 8 articles about 1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361215-49-7
((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate

: 153209-97-3
(3-methyloxetan-3-yl)methanamine

: 1361223-36-0
1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In methanol; at 140 ℃; for 0.5h;

Reference yield:

: 1255208-74-2
(3S)-3-((benzyloxy)methyl)-2,5-piperazinedione

: 1361223-36-0
1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C

3.1: sodium t-butanolate / toluene / 0.08 h

3.2: 12 h / 65 °C / Sealed tube

4.1: boron trichloride / dichloromethane / 0.67 h / 0 °C

5.1: triethylamine / dichloromethane

6.1: N-ethyl-N,N-diisopropylamine / methanol / 0.5 h / 140 °C

With lithium aluminium tetrahydride; boron trichloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 1361215-52-2
(3R)-3-((benzyloxy)methyl)-1-(2-thiophenylsulfonyl)piperazine

: 1361223-36-0
1,1,1-trifluoro-2-(4-((2S)-2-((((3-methyl-3-oxetanyl)methyl)amino)methyl)-4-(thiophen-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / toluene / 0.08 h

1.2: 12 h / 65 °C / Sealed tube

2.1: boron trichloride / dichloromethane / 0.67 h / 0 °C

3.1: triethylamine / dichloromethane

4.1: N-ethyl-N,N-diisopropylamine / methanol / 0.5 h / 140 °C

With boron trichloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In methanol; dichloromethane; toluene;