methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate

Base Information

Chemical Name:methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate
CAS No.:929517-33-9
Molecular Formula:C₂₀H₂₅NO₅
Molecular Weight:359.422
Hs Code.:

Synonyms:methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate

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Chemical Property of methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate

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Technology Process of methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate

There total 5 articles about methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 67-56-1
methanol

: 929517-32-8
(3S,4R)-3-hydroxy-4-(4-methoxyphenyl)-1-[(R)-1-(4-methoxyphenyl)ethyl]azetidin-2-one

: 929517-33-9
methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate

Guidance literature:: With chloro-trimethyl-silane; for 5h; Heating;
DOI:10.1021/ol062752p

Reference yield:

: 929517-37-3
(E)-(R)-N-(4-methoxybenzylidene)-1-(4-methoxyphenyl)ethanamine

: 929517-33-9
methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

2: 58 percent / KOH / tetrahydrofuran; H₂O / 2 h / 0 °C

3: 92 percent / chlorotrimethylsilane / 5 h / Heating

With potassium hydroxide; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; dichloromethane; water; 1: Staudinger reaction;
DOI:10.1021/ol062752p

Reference yield:

: 3-acetoxy-4-(4-methoxyphenyl)-1-[(R)-1-(4-methoxyphenyl)ethyl]azetidin-2-one

: 929517-33-9
methyl (2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-[((R)-1-(4-methoxyphenyl)ethyl)amino]propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / KOH / tetrahydrofuran; H₂O / 2 h / 0 °C

2: 92 percent / chlorotrimethylsilane / 5 h / Heating

With potassium hydroxide; chloro-trimethyl-silane; In tetrahydrofuran; water;
DOI:10.1021/ol062752p