(3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one

Base Information

Chemical Name:(3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one
CAS No.:1619258-07-9
Molecular Formula:C₃₀H₃₂Cl₂N₂O
Molecular Weight:507.503
Hs Code.:

Synonyms:(3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one

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Technology Process of (3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one

There total 3 articles about (3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 13061-96-6
dihydroxy-methyl-borane

: 1619258-06-8
(3S,5R,6S)-3-allyl-1-(1-(5-bromopyridin-2-yl)propyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methylpiperidin-2-one

: 1619258-07-9
(3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one

Guidance literature:: With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ml500142b

Reference yield:

: 1619258-01-3
C₈H₉Br₂N

: 1619258-07-9
(3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.13 h / 0 °C / Inert atmosphere

1.2: 3.17 h / 0 - 20 °C

2.1: tricyclohexylphosphine; potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With potassium phosphate; palladium diacetate; sodium hydride; tricyclohexylphosphine; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml500142b

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 1619258-07-9
(3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 4.25 h / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 0.45 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.13 h / 0 °C / Inert atmosphere

3.2: 3.17 h / 0 - 20 °C

4.1: tricyclohexylphosphine; potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With potassium phosphate; carbon tetrabromide; palladium diacetate; sodium hydride; triphenylphosphine; tricyclohexylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml500142b