2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid

Base Information

Chemical Name:2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid
CAS No.:1619257-76-9
Molecular Formula:C₂₉H₃₀Cl₂N₂O₃
Molecular Weight:525.475
Hs Code.:

Synonyms:2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid

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Chemical Property of 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid

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Technology Process of 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid

There total 3 articles about 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1619258-07-9
(3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one

: 1619257-76-9
2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 0.75h;
DOI:10.1021/ml500142b

Reference yield:

: 1619258-01-3
C₈H₉Br₂N

: 1619257-76-9
2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.13 h / 0 °C / Inert atmosphere

1.2: 3.17 h / 0 - 20 °C

2.1: tricyclohexylphosphine; potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.1: sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 0.75 h / 20 °C

With ruthenium trichloride; potassium phosphate; sodium periodate; palladium diacetate; sodium hydride; tricyclohexylphosphine; In tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/ml500142b

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 1619257-76-9
2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 4.25 h / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 0.45 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.13 h / 0 °C / Inert atmosphere

3.2: 3.17 h / 0 - 20 °C

4.1: tricyclohexylphosphine; potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

5.1: sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 0.75 h / 20 °C

With ruthenium trichloride; potassium phosphate; sodium periodate; carbon tetrabromide; palladium diacetate; sodium hydride; triphenylphosphine; tricyclohexylphosphine; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/ml500142b