(1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:178684-66-7
Molecular Formula:C₃₇H₄₂N₂O₆S
Molecular Weight:642.816
Hs Code.:

(1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of (1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

There total 6 articles about (1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96149-01-8
(1R,2R)-cyclopropane-1,2-dicarboxylic acid bis-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 178684-66-7
(1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 5 N aq. NaOH / propan-2-ol / 70 °C

2: SOCl₂ / Ambient temperature

3: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

4: ethanol; H₂O / 24 h / 55 °C

5: 1.) sodium bia(trimethylsilyl)amide / 1.) THF, RT, 30 min, 2.) THF, reflux, 16 h

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; zinc copper; sodium hexamethyldisilazane; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm970498o

Reference yield:

: 175415-91-5
(1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 178684-66-7
(1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / Ambient temperature

2: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

3: ethanol; H₂O / 24 h / 55 °C

4: 1.) sodium bia(trimethylsilyl)amide / 1.) THF, RT, 30 min, 2.) THF, reflux, 16 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; zinc copper; sodium hexamethyldisilazane; In ethanol; water;
DOI:10.1021/jm970498o

Reference yield:

: 178898-59-4
(1R,2R)-2-chlorocarbonyl-cyclopropanecarboxylic acid (1S,2R,5S)-5-isopropyl-2-methyl-cyclohexyl ester

: 178684-66-7
(1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

2: ethanol; H₂O / 24 h / 55 °C

3: 1.) sodium bia(trimethylsilyl)amide / 1.) THF, RT, 30 min, 2.) THF, reflux, 16 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc copper; sodium hexamethyldisilazane; In ethanol; water;
DOI:10.1021/jm970498o