(1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:201851-30-1
Molecular Formula:C₃₁H₃₈N₂O₄
Molecular Weight:502.654
Hs Code.:

(1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of (1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

There total 4 articles about (1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96149-01-8
(1R,2R)-cyclopropane-1,2-dicarboxylic acid bis-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 201851-30-1
(1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 5 N aq. NaOH / propan-2-ol / 70 °C

2: SOCl₂ / Ambient temperature

3: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

4: ethanol; H₂O / 24 h / 55 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; zinc copper; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm970498o

Reference yield:

: 175415-91-5
(1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 201851-30-1
(1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / Ambient temperature

2: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

3: ethanol; H₂O / 24 h / 55 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; zinc copper; In ethanol; water;
DOI:10.1021/jm970498o

Reference yield:

: 178898-59-4
(1R,2R)-2-chlorocarbonyl-cyclopropanecarboxylic acid (1S,2R,5S)-5-isopropyl-2-methyl-cyclohexyl ester

: 201851-30-1
(1R,2R)-2-[(S)-4-(2,2-Diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

2: ethanol; H₂O / 24 h / 55 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc copper; In ethanol; water;
DOI:10.1021/jm970498o