2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate

Base Information

• Chemical Name: 2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate
• CAS No.: 861657-83-2
• Molecular Formula: C₂₂H₂₉NO₇
• Molecular Weight: 419.475
• Mol file: 861657-83-2.mol

Synonyms:2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate

Chemical Property of 2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate

There total 1 articles about 2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-benzyl 1-tert-butyl 5-oxopyrrolidine-1,2-dicarboxylate (113400-36-5,400626-71-3) → 2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate (861657-83-2)

Guidance literature:

(S)-2-benzyl 1-tert-butyl 5-oxopyrrolidine-1,2-dicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tet.2007.03.084

Reference yield: 82.0%

2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate (861657-83-2) + 1.3-chlorobromopropane (109-70-6) → 2-benzyl 1,4-di-t-butyl 4-(3-chloropropyl)-5-oxo-1,2,4-pyrrolidinetricarboxylate

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; Heating;

DOI:10.1016/j.tet.2005.05.003

Reference yield: 62.0%

2-benzyl 1,4-di-t-butyl 5-oxo-1,2,4-pyrrolidinetricarboxylate (861657-83-2) → 2-benzyl 2,4-di-t-butyl 5-oxo-2,2,4-pyrrolidinetricarboxylate

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1016/j.tet.2005.05.003

upstream raw materials:

di-tert-butyl dicarbonate

(S)-2-benzyl 1-tert-butyl 5-oxopyrrolidine-1,2-dicarboxylate

Downstream raw materials:

2-benzyl 1,4-di-tert-butyl-4-[2-(chloromethyl)-2-propenyl]-5-oxo-1,2,4-pyrrolidinetricarboxylate