4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid

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Chemical Name:4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid
CAS No.:1194537-40-0
Molecular Formula:C₂₂H₂₁F₂N₅O₃
Molecular Weight:441.437
Hs Code.:

Synonyms:4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid

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Chemical Property of 4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid

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Technology Process of 4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid

There total 1 articles about 4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1194537-32-0
methyl 4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylate

: 1194537-40-0
4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid

Guidance literature:: methyl 4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylate; With methanol; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 10h;

With hydrogenchloride; water; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2009.08.021

Reference yield: 66.0%

: 1194537-40-0
4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1194537-48-8
4-[(3,5-difluorobenzyl)amino]-N-methoxy-N-methyl-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide

Guidance literature:: 4-[(3,5-difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2009.08.021