(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol

Base Information

Chemical Name:(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol
CAS No.:1229236-84-3
Molecular Formula:C₁₉H₁₉Cl₂FN₄O₂
Molecular Weight:425.29
Hs Code.:

Synonyms:(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol

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Technology Process of (4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol

There total 8 articles about (4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1229236-83-2
(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholino-methyl)imidazo[1,2-b]pyridazin-3-yl)methanone

: 1229236-84-3
(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol

Guidance literature:: With C₁₈H₂₃ClN₂O₂RuS; ammonium formate; In water; ethyl acetate; at 80 ℃; for 20h; Reagent/catalyst; Time; Concentration; chemoselective reaction; Inert atmosphere;
DOI:10.1002/cctc.201200526

Reference yield:

: C₁₅H₁₃Cl₂FN₄O

: 111-44-4
3-oxa-1,5-dichloropentane

: 1229236-84-3
(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol

Guidance literature:: With potassium carbonate; In water; at 80 ℃;
DOI:10.1021/op200229j

Reference yield:

: 1229236-79-6
(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide

: 1229236-84-3
(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium bromide / N,N-dimethyl-formamide / 30 h / 35 °C / Inert atmosphere; Large scale reaction

2: ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid / water; acetonitrile / 70 °C / Large scale reaction

3: hydrogenchloride; acetic acid / 100 °C

4: sodium tetrahydroborate / methanol / 5 °C

5: potassium carbonate / water / 80 °C

With hydrogenchloride; ammonium peroxydisulfate; sodium tetrahydroborate; potassium carbonate; silver nitrate; acetic acid; trifluoroacetic acid; sodium bromide; In methanol; water; N,N-dimethyl-formamide; acetonitrile; 1: Finkelstein reaction / 2: Minisci reaction;
DOI:10.1021/op200229j