(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanon

Base Information

Chemical Name:(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanon
CAS No.:1229236-80-9
Molecular Formula:C₁₄H₈Cl₂FN₃O
Molecular Weight:0
Hs Code.:

Synonyms:(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanon

Suppliers and Price of (4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanon

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of (4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanon

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanon

There total 3 articles about (4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.44%

: 1229236-79-6
(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide

: 299411-67-9
2-chloro-1-(4-chloro-2-fluorophenyl)ethan-1-one

: 1229236-80-9
(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo-[1,2-b]pyridazin-3-yl)methanone

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 5h; Product distribution / selectivity;

Reference yield: 72.0%

: 1229236-80-9
(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo-[1,2-b]pyridazin-3-yl)methanone

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

With sodium bromide; at 35 ℃; for 24h;

Reference yield:

: 175711-83-8
4’-chloro-2’-fluoroacetophenone

: 1229236-80-9
(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo-[1,2-b]pyridazin-3-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuryl dichloride / methanol; dichloromethane / 7 h / -5 - 0 °C / Large scale reaction

2: sodium bromide / N,N-dimethyl-formamide / 30 h / 35 °C / Inert atmosphere; Large scale reaction

With sulfuryl dichloride; sodium bromide; In methanol; dichloromethane; N,N-dimethyl-formamide; 2: Finkelstein reaction;
DOI:10.1021/op200229j