1229236-83-2

Usage

Uses

Given the provided materials, the exact uses of (4-Chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)-imidazo[1,2-b]pyridazin-3-yl)met are not explicitly stated. However, the presence of diverse chemical groups hints at potential applications in the following areas:
Used in Pharmaceutical Industry:
(4-Chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)-imidazo[1,2-b]pyridazin-3-yl)met could be used as a pharmaceutical compound for [application reason], given its complex structure that may offer unique therapeutic properties.
Used in Industrial Chemistry:
In the field of industrial chemistry, (4-Chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)-imidazo[1,2-b]pyridazin-3-yl)met might serve as a chemical intermediate or a component in the synthesis of other compounds for [application reason], due to its diverse functional groups.

Upstream product

• 299411-67-9 2-chloro-1-(4-chloro-2-fluorophenyl)ethan-1-one 
• 175711-83-8 4’-chloro-2’-fluoroacetophenone 
• 1229236-80-9 (4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo-[1,2-b]pyridazin-3-yl)methanone 
• 7529-22-8 4-methylmorpholine N-oxide 
• 1229236-79-6 (E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide 
• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 1229236-82-1 (8-(aminomethyl)-6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)(4-chloro-2-fluorophenyl)methanone 

Downstream Products

• 1229236-84-3 (4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol 
• 1229236-85-4 4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine 
• 1229236-86-5 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholino-methyl)imidazo[1,2-b]pyridazin-6-amine 
• 1346221-91-7 N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine 
• 1440192-12-0 C₁₉H₂₀ClFN₄O 
• 1440192-09-5 C₁₉H₂₀ClFN₄O₂ 
• 1440192-10-8 C₁₅H₁₃ClFN₃O 

Relevant academic research and scientific papers

IMIDAZO[1,2-B]PYRIDAZIN-6-AMINE DERIVATIVES AS KINASE JAK-2 INHIBITORS

A compound represented by the general formula (I) wherein R1represents H or C1-C4 alkyl; R2 represents phenyl substituted with one or two substituents selected from the group consisting of halogen atom and OCsu

Development and a practical synthesis of the JAK2 inhibitor LY2784544

The route selection and process research and development of a practical synthesis for JAK2 inhibitor LY2784544 is described. The first-generation synthesis route, similar to that used in discovery for derivatization of a benzylic amine moiety, was 14 overall steps and possessed several steps that required extensive development for large-scale production. Route selection considerations led to a modified synthesis that utilized a novel vanadium-catalyzed carbon-carbon bond-forming arylation reaction for incorporation of the key benzylic morpholine moiety. A protecting group used to mask an amino pyrazole unit was modified from PMB to tert-butyl, resulting in a dramatic reduction in the overall length of the route. These two major changes resulted in an eight-step synthesis, which was six steps shorter than the first-generation synthesis. In the pilot plant, the new synthesis was scaled to produce >100 kg of LY2784544 in high yield and purity under GMP conditions. The overall development including the vanadium-catalyzed C-C bond-forming methodology, a ketone reductive deoxygenation, and a palladium-catalyzed amination is described.

AMINO PYRAZOLE COMPOUND

The present invention provides amino pyrazole compounds useful in the treatment of chronic myeloproliferative disorders and various cancers, e.g., glioblastoma, breast cancer, multiple myeloma, prostate cancer, and leukemias.