N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate

Base Information

• Chemical Name: N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate
• CAS No.: 895153-67-0
• Molecular Formula: C₂₄H₃₀Cl₃NO₅
• Molecular Weight: 518.865
• Mol file: 895153-67-0.mol

Synonyms:N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate

Chemical Property of N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate

There total 2 articles about N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2'-cyclopentyl-2'-phenyl-2'-hydroxyacetic acid 9α-[3-methyl-3-azabicyclo(3.3.1)nonan-9-yl]ester hydrochloride (172451-71-7) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate (895153-67-0)

Guidance literature:

2'-cyclopentyl-2'-phenyl-2'-hydroxyacetic acid 9α-[3-methyl-3-azabicyclo(3.3.1)nonan-9-yl]ester hydrochloride; With ammonia; In diethyl ether; water;

2,2,2-Trichloroethyl chloroformate; With potassium carbonate; In benzene; at 85 ℃; for 5h;

Reference yield: 91.0%

N-methyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate (895153-67-0)

Guidance literature:

In benzene; for 20h; Heating;

DOI:10.1081/SCC-200057293

Reference yield: 80.0%

N-trichloroethoxyformyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate (895153-67-0) → 3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate (895153-68-1)

Guidance literature:

With acetic acid; zinc; at 20 ℃; for 5h;

DOI:10.1081/SCC-200057293

upstream raw materials:

2,2,2-Trichloroethyl chloroformate

2'-cyclopentyl-2'-phenyl-2'-hydroxyacetic acid 9α-[3-methyl-3-azabicyclo(3.3.1)nonan-9-yl]ester hydrochloride

Downstream raw materials:

3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate