3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Base Information

Chemical Name:3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate
CAS No.:1192189-85-7
Molecular Formula:C₂₉H₃₂N₆O₄
Molecular Weight:528.611
Hs Code.:

Synonyms:3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

There total 8 articles about 3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192189-89-1
3-[4-(benzyloxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

: 1618-36-6
4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine

: 1192189-85-7
3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 110 ℃; for 17h;

Reference yield:

: 1192189-87-9
4-benzyloxy-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

: 1192189-85-7
3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

3.1: isopropyl alcohol / 17 h / 110 °C / Inert atmosphere; High pressure

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml500367g

Reference yield:

: 1192189-88-0
tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

: 1192189-85-7
3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

2: isopropyl alcohol / 17 h / 110 °C / Inert atmosphere; High pressure

With hydrogenchloride; methanol; In 1,4-dioxane; isopropyl alcohol;
DOI:10.1021/ml500367g