3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Base Information

Chemical Name:3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate
CAS No.:1192189-90-4
Molecular Formula:C₂₂H₂₆N₆O₄
Molecular Weight:438.486
Hs Code.:

Synonyms:3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Suppliers and Price of 3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

There total 8 articles about 3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192189-85-7
3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

: 1192189-90-4
3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: 3-[4-benzyloxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate; With hydrogen; Pd(OH)2/C; In methanol; for 24h; under 3102.97 Torr;

With trifluoroacetic acid; In methanol; for 72h; under 3102.97 Torr;

Reference yield:

: 1192189-87-9
4-benzyloxy-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

: 1192189-90-4
3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

3.1: isopropyl alcohol / 17 h / 110 °C / Inert atmosphere; High pressure

4.1: 10 wt% Pd(OH)2 on carbon; hydrogen; trifluoroacetic acid / methanol / 72 h / 3102.97 Torr

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; 10 wt% Pd(OH)2 on carbon; hydrogen; N,N-dimethyl-formamide; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml500367g

Reference yield:

: 1192189-88-0
tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

: 1192189-90-4
3-[4-hydroxy-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

2: isopropyl alcohol / 17 h / 110 °C / Inert atmosphere; High pressure

3: 10 wt% Pd(OH)2 on carbon; hydrogen; trifluoroacetic acid / methanol / 72 h / 3102.97 Torr

With hydrogenchloride; methanol; 10 wt% Pd(OH)2 on carbon; hydrogen; trifluoroacetic acid; In 1,4-dioxane; methanol; isopropyl alcohol;
DOI:10.1021/ml500367g