tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate
CAS No.:1192189-88-0
Molecular Formula:C₂₇H₃₅N₃O₆
Molecular Weight:497.591
Hs Code.:

Synonyms:tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₄ClNO₄

: 19962-04-0
Dimethylcarbaminsaeure-3-aminophenylester

: 1192189-88-0
tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: With pyridine; In dichloromethane; for 0.5h;

Reference yield:

: 1192189-87-9
4-benzyloxy-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

: 19962-04-0
Dimethylcarbaminsaeure-3-aminophenylester

: 1192189-88-0
tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: 4-benzyloxy-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid; With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

Dimethylcarbaminsaeure-3-aminophenylester; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ml500367g

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1192189-88-0
tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate; water / methanol / 0.5 h / 60 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 0.5 h / 20 °C / Inert atmosphere

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml500367g