(3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

Base Information

Chemical Name:(3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone
CAS No.:321887-28-9
Molecular Formula:C₃₄H₃₁NO₄
Molecular Weight:517.624
Hs Code.:

Synonyms:(3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

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Chemical Property of (3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

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Technology Process of (3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

There total 3 articles about (3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 100-39-0
benzyl bromide

: 321887-26-7
(3S,4S,5S)-3-hydroxy-4-hydroxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

: 321887-28-9
(3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

Guidance literature:: (3S,4S,5S)-3-hydroxy-4-hydroxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

benzyl bromide; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jo0012187

Reference yield:

: 106318-93-8
phenylpropargylidene p-anisidine

: 321887-28-9
(3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: HMDS; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 47 percent / tetrahydrofuran / 1.5 h / -78 - 0 °C

2.1: 91 percent / NaBH₄; LiCl / bis-(2-methoxy-ethyl) ether / 24 h / 20 °C

3.1: NaH / dimethylformamide / 0.5 h

3.2: 86 percent / 1 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane; lithium chloride; In tetrahydrofuran; hexane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo0012187

Reference yield:

: 173095-49-3
(3S,4R,5S)-4-ethoxycarbonyl-3-hydroxy-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

: 321887-28-9
(3S,4S,5S)-3-benzyloxy-4-benzyloxymethyl-1-(4-methoxyphenyl)-5-phenylpropargyl-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / NaBH₄; LiCl / bis-(2-methoxy-ethyl) ether / 24 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h

2.2: 86 percent / 1 h / 20 °C

With sodium tetrahydroborate; sodium hydride; lithium chloride; In diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo0012187