(S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

Base Information

• Chemical Name: (S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester
• CAS No.: 92917-67-4
• Molecular Formula: C₂₄H₃₁N₃O₅
• Molecular Weight: 441.527
• Mol file: 92917-67-4.mol

Synonyms:(S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

Chemical Property of (S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

There total 3 articles about (S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Ala-Lys(Z)-OBzl (114856-02-9) → (S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester (92917-67-4)

Guidance literature:

With TFA-anisole; at 0 ℃; for 0.666667h;

DOI:10.1248/cpb.36.700

Reference yield:

Lys(Z)-OBzl (24458-14-8) → (S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester (92917-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / N-methylmorpholine / dimethylformamide / 5 h / Ambient temperature

2: TFA-anisole / 0.67 h / 0 °C

With 4-methyl-morpholine; TFA-anisole; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.700

Reference yield:

N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester (77236-13-6) → (S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester (92917-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1: TFA-anisole / 0.67 h / 0 °C

2: 96 percent / N-methylmorpholine / dimethylformamide / 5 h / Ambient temperature

3: TFA-anisole / 0.67 h / 0 °C

With 4-methyl-morpholine; TFA-anisole; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.700

upstream raw materials:

Boc-Ala-Lys(Z)-OBzl

Lys(Z)-OBzl

N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester

Downstream raw materials:

Boc-Gln-Ala-Lys(Z)-OBzl

Boc-Pro-Ala-Lys(Z)-OBzl

Boc-Gln-Glu(OcHex)-Lys(Z)-Gln-Ala-Lys(Z)-OBzl

Boc-Lys(Z)-Gln-Ala-Lys(Z)-OBzl