Technology Process of (R)-2-(1-acetyl-1,4,5,6-tetrahydropyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
There total 1 articles about (R)-2-(1-acetyl-1,4,5,6-tetrahydropyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl pyrrolidine-1-carboxylate;
With
C13H26N2; sec.-butyllithium; (-)-sparteine;
In
hexane; tert-butyl methyl ether;
at -78 ℃;
for 1.5h;
Inert atmosphere;
With
zinc(II) chloride;
In
diethyl ether; hexane; tert-butyl methyl ether;
at -78 - 20 ℃;
Inert atmosphere;
1-(5-bromo-1,2,3,4-tetrahydropyridin-1-yl)ethan-1-one;
With
tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate;
In
diethyl ether; hexane; tert-butyl methyl ether;
at 20 ℃;
for 72h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/jo2011347
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jo2011347
