Technology Process of (+)-maackiamine
There total 5 articles about (+)-maackiamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jo2011347
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 16 h / 50 °C / Inert atmosphere
2.1: bromine / dichloromethane / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: C13H26N2; sec.-butyllithium; (-)-sparteine / hexane; tert-butyl methyl ether / 1.5 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
3.3: 72 h / 20 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
C13H26N2; bromine; sec.-butyllithium; trifluoroacetic acid; (-)-sparteine;
In
hexane; dichloromethane; tert-butyl methyl ether;
3.3: Negishi coupling reaction;
DOI:10.1021/jo2011347
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bromine / dichloromethane / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: C13H26N2; sec.-butyllithium; (-)-sparteine / hexane; tert-butyl methyl ether / 1.5 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
2.3: 72 h / 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
C13H26N2; bromine; sec.-butyllithium; trifluoroacetic acid; (-)-sparteine;
In
hexane; dichloromethane; tert-butyl methyl ether;
2.3: Negishi coupling reaction;
DOI:10.1021/jo2011347
