1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Base Information

Chemical Name:1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester
CAS No.:573658-98-7
Molecular Formula:C₃₁H₄₄FNO₃Si
Molecular Weight:525.779
Hs Code.:

Synonyms:1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Suppliers and Price of 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

There total 3 articles about 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 573658-98-7
1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylsulfoxide

2: DIBAL / CH₂Cl₂ / -78 °C

3: NaB(OAc)3H / CH₂Cl₂

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol034707c

Reference yield:

: 208662-12-8
dibenzyl cyclopentane-1,1-dicarboxylate

: 573658-98-7
1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DIBAL / CH₂Cl₂ / -78 °C

2: NaB(OAc)3H / CH₂Cl₂

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/ol034707c