Technology Process of 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-methyl-N-(methyloxy)-1,3-thiazol-4-carboxamide
There total 6 articles about 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-methyl-N-(methyloxy)-1,3-thiazol-4-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / 2 h / Heating / reflux
2.1: iodine; silver nitrate / ethanol / 16 h / Heating / reflux
3.1: water / ethanol / 1.5 h / 90 °C
4.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C
5.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C
6.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h
6.2: 0.02 h
6.3: 1.5 h / 0 - 20 °C
7.1: sodium hydroxide; water / ethanol / 20 - 60 °C
8.1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C
With
Lawessons reagent; 4-methyl-morpholine; sodium hydroxide; N-hydroxybenzotriazole ammonium salt; water; iodine; potassium carbonate; benzotriazol-1-ol; potassium hydrogencarbonate; silver nitrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
1,2-dimethoxyethane; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h
1.2: 0.02 h
1.3: 1.5 h / 0 - 20 °C
2.1: sodium hydroxide; water / ethanol / 20 - 60 °C
3.1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C
With
4-methyl-morpholine; sodium hydroxide; water; benzotriazol-1-ol; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
1,2-dimethoxyethane; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C
2.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h
2.2: 0.02 h
2.3: 1.5 h / 0 - 20 °C
3.1: sodium hydroxide; water / ethanol / 20 - 60 °C
4.1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C
With
Lawessons reagent; 4-methyl-morpholine; sodium hydroxide; water; benzotriazol-1-ol; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
1,2-dimethoxyethane; ethanol; dichloromethane;
