3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

Base Information

• Chemical Name: 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride
• CAS No.: 1345337-40-7
• Molecular Formula: C₂₀H₁₂Cl₂N₈O*ClH
• Molecular Weight: 487.735
• Mol file: 1345337-40-7.mol

Synonyms:3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

Chemical Property of 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

There total 14 articles about 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile (1345336-22-2) → 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride (1345337-40-7)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; water; Inert atmosphere;

DOI:10.1021/jm2010173

Reference yield:

3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile (1345337-24-7) → 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride (1345337-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 2 h / 75 °C / Inert atmosphere

2: hydrogenchloride / methanol; chloroform; water / Inert atmosphere

With hydrogenchloride; trifluoroacetic acid; In methanol; chloroform; water;

DOI:10.1021/jm2010173

Reference yield:

3-(chloromethyl)-N,2-bis(4-methoxybenzyl)-2H-pyrazolo[3,4-b]pyridin-6-amine (1345337-21-4) → 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride (1345337-40-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium tert-butoxide / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic acid / 2 h / 75 °C / Inert atmosphere

3.1: hydrogenchloride / methanol; chloroform; water / Inert atmosphere

With hydrogenchloride; trifluoroacetic acid; lithium tert-butoxide; In methanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1021/jm2010173

upstream raw materials:

tert-butyl 6-fluoro-2-(4-methoxybenzyl)-2H-pyrazolo[3,4-b]pyridine-3-carboxylate

3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

3-(chloromethyl)-N,2-bis(4-methoxybenzyl)-2H-pyrazolo[3,4-b]pyridin-6-amine

3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile