3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile

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Chemical Name:3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile
CAS No.:1345336-22-2
Molecular Formula:C₂₀H₁₂Cl₂N₈O
Molecular Weight:451.274
Hs Code.:

Synonyms:3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile

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Chemical Property of 3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile

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Technology Process of 3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile

There total 13 articles about 3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1345337-24-7
3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

: 1345336-22-2
3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile

Guidance literature:: With trifluoroacetic acid; at 75 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm2010173

Reference yield:

: 1345337-21-4
3-(chloromethyl)-N,2-bis(4-methoxybenzyl)-2H-pyrazolo[3,4-b]pyridin-6-amine

: 1345336-22-2
3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium tert-butoxide / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic acid / 2 h / 75 °C / Inert atmosphere

With trifluoroacetic acid; lithium tert-butoxide; In N,N-dimethyl-formamide;
DOI:10.1021/jm2010173

Reference yield:

: C₂₇H₃₀N₄O₄

: 1345336-22-2
3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-1,2,3-benzotriazol-4-yl}oxy)-5-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2.1: thionyl chloride / chloroform / 20 °C / Cooling with ice; Inert atmosphere

3.1: lithium tert-butoxide / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

3.2: Inert atmosphere

4.1: trifluoroacetic acid / 2 h / 75 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; trifluoroacetic acid; lithium tert-butoxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm2010173