3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

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Chemical Name:3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile
CAS No.:1345337-24-7
Molecular Formula:C₃₆H₂₈Cl₂N₈O₃
Molecular Weight:691.576
Hs Code.:

3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

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Chemical Property of 3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

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Technology Process of 3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

There total 12 articles about 3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.5%

: 1034474-39-9
3-chloro-5-[(5-chloro-1H-1,2,3-benzotriazol-4-yl)oxy]benzonitrile

: 1345337-21-4
3-(chloromethyl)-N,2-bis(4-methoxybenzyl)-2H-pyrazolo[3,4-b]pyridin-6-amine

: 1345337-24-7
3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

: 3-chloro-5-{[5-chloro-2-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridine-3-yl}methyl)-2H-1,2,3-benzotriazol-4-yl]-oxy}benzonitrile

Guidance literature:: 3-chloro-5-[(5-chloro-1H-1,2,3-benzotriazol-4-yl)oxy]benzonitrile; With lithium tert-butoxide; In N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere;

3-(chloromethyl)-N,2-bis(4-methoxybenzyl)-2H-pyrazolo[3,4-b]pyridin-6-amine; In N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/jm2010173

Reference yield:

: C₂₇H₃₀N₄O₄

: 1345337-24-7
3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

: 3-chloro-5-{[5-chloro-2-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridine-3-yl}methyl)-2H-1,2,3-benzotriazol-4-yl]-oxy}benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2.1: thionyl chloride / chloroform / 20 °C / Cooling with ice; Inert atmosphere

3.1: lithium tert-butoxide / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

3.2: Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; lithium tert-butoxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm2010173

Reference yield:

: C₂₃H₂₄N₄O₃

: 1345337-24-7
3-chloro-5-{[5-chloro-1-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

: 3-chloro-5-{[5-chloro-2-({2-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-2H-pyrazolo[3,4-b]pyridine-3-yl}methyl)-2H-1,2,3-benzotriazol-4-yl]-oxy}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / chloroform / 20 °C / Cooling with ice; Inert atmosphere

2.1: lithium tert-butoxide / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

2.2: Inert atmosphere

With thionyl chloride; lithium tert-butoxide; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm2010173