N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate

Base Information

Chemical Name:N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate
CAS No.:1372179-99-1
Molecular Formula:C₄H₄O₄*C₁₃H₁₆Cl₂N₂O₂
Molecular Weight:419.262
Hs Code.:

Synonyms:N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate

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Chemical Property of N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate

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Technology Process of N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate

There total 12 articles about N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372187-05-7
tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1372179-99-1
N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate

Guidance literature:: tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate; With hydrogenchloride; In ethyl acetate; at 10 - 35 ℃; for 1h;

(2E)-but-2-enedioic acid; In ethanol;

Reference yield:

: 1372187-02-4
(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-6-carboxylic acid

: 1372179-99-1
N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 90 °C

1.2: 2 h / 90 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 50 °C

3.1: triethylamine / tetrahydrofuran / 0 - 35 °C

4.1: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; ethyl acetate; toluene; 1.1: Curtius Rearrangement;

Reference yield:

: 1372187-01-3
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-formyl-1,4-oxazepane-4-carboxylate

: 1372179-99-1
N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetamide monofumarate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-methyl-but-2-ene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 2 h / Cooling with ice

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 90 °C

2.2: 2 h / 90 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 50 °C

4.1: triethylamine / tetrahydrofuran / 0 - 35 °C

5.1: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; water; ethyl acetate; toluene; tert-butyl alcohol; 2.1: Curtius Rearrangement;