tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Base Information

Chemical Name:tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate
CAS No.:1372187-05-7
Molecular Formula:C₁₈H₂₄Cl₂N₂O₄
Molecular Weight:403.306
Hs Code.:

Synonyms:tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

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Chemical Property of tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Chemical Property:

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Technology Process of tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

There total 12 articles about tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372187-04-6
tert-butyl (6R,7S)-6-amino-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 75-36-5
acetyl chloride

: 1372187-05-7
tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 35 ℃;

Reference yield:

: 1372187-01-3
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-formyl-1,4-oxazepane-4-carboxylate

: 1372187-05-7
tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2-methyl-but-2-ene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 2 h / Cooling with ice

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 90 °C

2.2: 2 h / 90 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 50 °C

4.1: triethylamine / tetrahydrofuran / 0 - 35 °C

With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; water; toluene; tert-butyl alcohol; 2.1: Curtius Rearrangement;

Reference yield:

: 1372187-02-4
(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-6-carboxylic acid

: 1372187-05-7
tert-butyl (6R,7S)-6-(acetylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 90 °C

1.2: 2 h / 90 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 50 °C

3.1: triethylamine / tetrahydrofuran / 0 - 35 °C

With diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; toluene; 1.1: Curtius Rearrangement;