(Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one

Base Information

• Chemical Name: (Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one
• CAS No.: 1338081-29-0
• Molecular Formula: C₁₄H₁₃F₃N₂O₂
• Molecular Weight: 298.265

Synonyms:(Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one

Chemical Property of (Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one

Chemical Property:

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Technology Process of (Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one

There total 2 articles about (Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(Z)-4-(2-methoxy-5-(trifluoromethyl)benzylidene)-2-methyl-4H-oxazol-5-one (1338081-28-9) + methylamine (74-89-5) → (Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one (1338081-29-0)

Guidance literature:

With potassium carbonate; In ethanol; water; for 4h; Reflux;

DOI:10.1021/jo2012384

Reference yield:

2-methoxy-5-(trifluoromethyl)benzaldehyde (146539-83-5) → (Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one (1338081-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic anhydride / 4 h / 80 °C

2: potassium carbonate / ethanol; water / 4 h / Reflux

With sodium acetate; potassium carbonate; In ethanol; water; acetic anhydride;

DOI:10.1021/jo2012384

Reference yield: 84.0%

(Z)-5-(2-methoxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one (1338081-29-0) → (Z)-5-(2-hydroxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one (1338081-30-3)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo2012384

upstream raw materials:

(Z)-4-(2-methoxy-5-(trifluoromethyl)benzylidene)-2-methyl-4H-oxazol-5-one

methylamine

2-methoxy-5-(trifluoromethyl)benzaldehyde

Downstream raw materials:

(Z)-5-(2-hydroxy-5-(trifluoromethyl)benzylidene)-2,3-dimethyl-3,5-dihydroimidazol-4-one

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