2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion

Base Information

Chemical Name:2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion
CAS No.:286374-81-0
Molecular Formula:C₁₉H₁₁F₃N₂O₂S₂
Molecular Weight:420.436
Hs Code.:

Synonyms:2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion

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Chemical Property of 2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion

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Technology Process of 2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion

There total 4 articles about 2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1074-82-4
potassium phtalimide

: 286374-52-5
4-Chlormethyl-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-2-thion

: 286374-81-0
2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion

Guidance literature:: 18-crown-6 ether; In toluene; for 2h; Heating;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 286374-81-0
2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion

Guidance literature:: Multi-step reaction with 4 steps

1: 30.12 g / 20 °C

2: 80 percent / methanol; acetone / 2 h / 20 °C

3: 22.08 g / HCl / ethyl acetate / 2 h / Heating

4: 92 percent / 18-crown-6 / toluene / 2 h / Heating

With hydrogenchloride; 18-crown-6 ether; In methanol; ethyl acetate; acetone; toluene; 1: Addition / 2: Cyclization / 3: Dehydration / 4: Substitution;

Reference yield:

: 286374-46-7
4-Chlormethyl-4-hydroxy-3-(3-trifluormethylphenyl)-1,3-thiazolidin-2-thion

: 286374-81-0
2-[2-Thioxo-3-(3-trifluormethylphenyl)-2,3-dihydro-1,3-thiazol-4-ylmethyl]isoindolin-1,3-dion

Guidance literature:: Multi-step reaction with 2 steps

1: 22.08 g / HCl / ethyl acetate / 2 h / Heating

2: 92 percent / 18-crown-6 / toluene / 2 h / Heating

With hydrogenchloride; 18-crown-6 ether; In ethyl acetate; toluene; 1: Dehydration / 2: Substitution;