Technology Process of 3-bromo-4-iodophenyl methanesulfonate
There total 4 articles about 3-bromo-4-iodophenyl methanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-amino-3-bromophenyl methanesulfonate;
With
sulfuric acid;
In
water; acetonitrile;
at 0 ℃;
for 0.166667h;
With
sodium nitrite;
In
water; acetonitrile;
at 0 - 5 ℃;
for 1.5h;
With
potassium iodide;
In
water; acetonitrile;
at 0 ℃;
for 0.25h;
DOI:10.1021/ol400597f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 3 h / 20 °C / 51683.5 Torr
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C
3.1: sulfuric acid / water; acetonitrile / 0.17 h / 0 °C
3.2: 1.5 h / 0 - 5 °C
3.3: 0.25 h / 0 °C
With
N-Bromosuccinimide; sulfuric acid; palladium 10% on activated carbon; hydrogen;
In
ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol400597f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 0.75 h / 0 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 3 h / 20 °C / 51683.5 Torr
3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C
4.1: sulfuric acid / water; acetonitrile / 0.17 h / 0 °C
4.2: 1.5 h / 0 - 5 °C
4.3: 0.25 h / 0 °C
With
N-Bromosuccinimide; sulfuric acid; palladium 10% on activated carbon; hydrogen; triethylamine;
In
ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol400597f
