(2R)-2-(2,5-difluorophenyl)-1-{pyrazolo[1,5-a]pyrimidin-5-yl}pyrrolidine

Base Information

Chemical Name:(2R)-2-(2,5-difluorophenyl)-1-{pyrazolo[1,5-a]pyrimidin-5-yl}pyrrolidine
CAS No.:1223404-89-4
Molecular Formula:C₁₆H₁₄F₂N₄
Molecular Weight:300.311
Hs Code.:
Mol file:1223404-89-4.mol

Synonyms:(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine

Suppliers and Price of (2R)-2-(2,5-difluorophenyl)-1-{pyrazolo[1,5-a]pyrimidin-5-yl}pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 12 raw suppliers

Chemical Property of (2R)-2-(2,5-difluorophenyl)-1-{pyrazolo[1,5-a]pyrimidin-5-yl}pyrrolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R)-2-(2,5-difluorophenyl)-1-{pyrazolo[1,5-a]pyrimidin-5-yl}pyrrolidine

There total 6 articles about (2R)-2-(2,5-difluorophenyl)-1-{pyrazolo[1,5-a]pyrimidin-5-yl}pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1218935-60-4,1197238-95-1,1443624-23-4
(2R)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride

: 29274-24-6
5-chloropyrazolo[1,5-a]pyrimidine

: 1223404-89-4
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 140 ℃;
DOI:10.1021/acs.jmedchem.1c01539

Reference yield: 74.0%

: 1218935-59-1,1217630-38-0
(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine

: 29274-24-6
5-chloropyrazolo[1,5-a]pyrimidine

: 1223404-89-4
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: With potassium fluoride; In dimethyl sulfoxide; at 180 ℃; for 2h;

Reference yield:

: 29274-22-4
pyrazolo[1,5-a]pyrimidine-5-ol

: 1223404-89-4
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 3 h / Reflux

2: potassium fluoride / dimethyl sulfoxide / 2 h / 180 °C

With potassium fluoride; trichlorophosphate; In dimethyl sulfoxide;