(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine

Base Information

• Chemical Name: (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine
• CAS No.: 1223404-90-7
• Molecular Formula: C₁₆H₁₃F₂N₅O₂
• Molecular Weight: 345.308
• Mol file: 1223404-90-7.mol

Synonyms:(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine

Chemical Property of (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine

Chemical Property:

• PKA: -0.73±0.40(Predicted)
• Density: 1.58±0.1 g/cm3(Predicted)

Purity/Quality:

≥98.0% ^*data from raw suppliers

(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine ^*data from reagent suppliers

Safty Information:

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Technology Process of (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine

There total 16 articles about (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine (1218935-59-1,1217630-38-0) + 5-chloro-3-nitropyrazolo[1,5-a]pyrimidine (1363380-51-1) → (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine (1223404-90-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 50 ℃; for 5h;

Reference yield: 92.3%

(2R)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride (1218935-60-4,1197238-95-1,1443624-23-4) + 5-chloro-3-nitropyrazolo[1,5-a]pyrimidine (1363380-51-1) → (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine (1223404-90-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; ethanol; at 50 ℃; for 5h;

Reference yield: 58.0%

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine (1223404-89-4) → (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine (1223404-90-7)

Guidance literature:

With nitric acid; trifluoroacetic acid; at 20 ℃;

upstream raw materials:

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine

3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one

5-chloro-3-nitropyrazolo[1,5-a]pyrimidine

(R)-2-(2,5-difluorophenyl)-pyrrolidine (R)-2-hydroxy-succinate

Downstream raw materials:

5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine

phenyl (5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3,3a-dihydropyrazolo[1,5-a]pyrimidin-3-yl)carbamate

(S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

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